Humberto Maturana. My purpose in this article is to present a theory of the organization of living systems as autonomous entities, and a theory of the organization of the nervous system as a closed network of interacting neurons structurally coupled to the living system to whose realization it contributes. The fundamental feature that characterizes living systems is autonomy, and any account of their organization as systems that can exist as individual unities must show what autonomy is as a phenomenon proper to them, and how it arises in their operation as such unities. Accordingly the following is proposed. That autonomy in living systems is a feature of self-production (autopoiesis), and that a living system is properly characterized only as a network of processes of production of components that is continuously, and recursively, generated and realized as a concrete entity (unity) in the physical space, by the interactions of the same components that it produces as such a network. This organization I call the autopoietic organization, and any system that exhibits it is an autopoietic system in the space in which its components exist; in this sense living systems are autopoietic systems in the physical space.
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